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UNAIR students design methods for Covid-19 diagnosis and treatment based on CRISPR-Cas13 Genetic Engineering Technology

Three UNAIR students awarded as Runner-up in the 2021 International Essay Competition. (Photo: By courtesy)

UNAIR NEWS聽鈥� Ilham Rahmanto, Ardelia Bertha Prastika, and Salsabila Farah Rafidah are three students winning the聽Runner-up聽position聽in the聽2021聽International Essay Competition.聽Ilham as the team leader, revealed that through a competition held by the Faculty of Medicine (FK) Universitas Sebelas Maret (UNS), the students could generate their creative ideas in dealing with the pandemic.

Starting from Ilham, Ardel, and Salsa鈥檚 concern about the Covid-19 diagnosis method, which still has many weaknesses, the three came up with an alternative method using the CRISPR-Cas13 genetic engineering technology based on聽gold nanoparticles.聽CRISPR is a bacterial defense mechanism to fight foreign genetic material such as viruses and plasmids by cutting the foreign DNA.

鈥淯ntil now, there is still no definite cure for Covid-19. The vaccination program run by the government also only aims to prevent, and it turns out that CRISPR technology has the potential to be the latest treatment for COVID-19, 鈥渆xplained Ilham.

Furthermore, Ilham explained that he and his team designed a strip that utilizes the genetic engineering technology CRISPR-Cas13 to detect the SARS-CoV-2 virus in less than an hour.聽According to Ilham, the strips have specifications that are not much different from RT-PCR as the聽gold standard.

鈥淲e also designed an aerosol drug that uses the genetic engineering technology CRISPR-Cas13 to treat COVID-19 directly in lung epithelial cells, which is the most common location for SARS-CoV-2,鈥� he added on Monday, July 26, 2021.

CRISPR-Cas13 Genetic Engineering Technology Mechanism as a COVID-19 treatment. (Illustration by UNAIR team)
CRISPR-Cas13 Genetic Engineering Technology Mechanism to detect SARS-CoV-2 virus. (Illustration by UNAIR team)

Before participating in the competition, Ilham and his team had made extensive preparation.聽They had聽brainstorming sessions and agreed on some ideas, essay drafting to mechanisms and products illustration making.

鈥淲hen we were declared聽runners-up,聽we felt grateful because we were able to qualify among other equally great ideas.聽We are also motivated more to provide other ideas to help the Indonesian government overcome the pandemic,鈥� said Ilham.

Finally, Ilham advised other students to get out of their comfort zone to become great students. What is needed now, he continued, is the courage to decide.

鈥淭he pandemic does limit our communication, but the pandemic cannot limit our desire to excel,鈥� he concluded. (*)

Author: Dita Aulia Rahma

Editor: Binti Q. Masruroh

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