UNAIR NEWS –聽International Diabetes Federation聽(IDF) released that 90% of people worldwide have聽type II聽diabetes mellitus聽(DM).聽In Indonesia, based on the results of Health Research Ministry of Health, 6.9% of 176,689,336 people aged 15 years and above or about 12,191,564 people suffering from DM type II.
Type II DM patients are generally not aware that they suffered from the disease.聽They only realize when there is a discomfort or a real sign such as blackened lesions and ulcers.聽The injury in type II DM patients occurs because there are certain areas in the body of patients experiencing oxygen deficiency due to improper blood circulation.
Reduced levels of oxidative stress on the tissue become the main principle in its healing.聽The sources of oxidative stress that result from increased free radical production due to聽glucose autooxydation decrease concentrations of low molecular weight antioxidants in the tissues, and impair enzymatic antioxidant defense activity.
Based on the problem, PKM-PE team of 聽from Faculty of Fishery and Marine (FPK) succeeded to make an ointment that can be used to accelerate wound healing due to DM type II.聽The PKM-PE team consists of Aida Nuraini, Siti Nur Rohmah and Rizky Yanuar Rahmadan.
Under the guidance of Dr.聽Laksmi Sulmartiwi, S.Pi., MP., their research proposal was entitled “The Combination of Albumin of Striped snakehead fish (聽Channa striata聽) with Astaxantin Antioxidant Action in Commercial Ointment as an Effort to Accelerate Wound Healing of Type II Diabetes Mellitus” passed Kemenristekdikti assessment, so it is entitled to a research grant in the 2018 PKM Program.
“We have an alternative solution to solve this problem, that is by making an ointment formulated with striped snakehead fish鈥檚 albumin and聽astaxantin聽as a treatment step of聽type II聽diabetes mellitus聽wound聽,” said Aida Nuraini, head of PKM-PE team.
The students who are currently taking the fourth semester said the handling聽of聽type II聽diabetes wound, so far still a preventive effort.聽There is still no specific treatment addressing the source of the problem, ie cell damage and聽oxidative stress.聽Proper handling to the cause of the disease certainly accelerates the process of healing and recovery of wounds.
Aida further stated that striped snakehead fish (聽Channa striata聽) is a fish that has the potential to be used in the accelerating process of healing and recovery of wounds caused by type II DM.聽This is because it contains聽globular聽protein聽called albumin which is useful for wound healing.
“Albumin has a uniqueness, which is able to stimulate聽cell聽proliferation聽so that cells that have died can be replaced or regenerated by new cells.聽In addition it is also used聽astaxantin聽very potential to ward off the effects of聽oxidative stress聽in diabetic wounds, “added Aida.
It was also聽explained聽that聽Astaxantin聽works by reducing the production of聽reactive oxygen species聽(ROS) in the wound, thus minimizing the occurrence of聽oxidative stress聽that inhibits healing.
In order to see the potential of the formulation, Aida and friends conducted a series of tests.聽One of them is聽in vivo聽test聽to measure wound healing rate of diabetes through measurement of epithelial index on tissue in the wound.
“We hope this research can be an innovative treatment of diabetes mellitus聽type II wounds聽 that can be utilized in the future,” said Aida Nuraini.聽(*)
Editor: Bambang Bes
